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This course will prepare students to meet the challenges associated with caring for adults and children experiencing acute and chronic illnesses involving core body systems. Nursing interventions for persons across the lifespan will be a central theme. Emphasis will be placed on assessing how illness impacts the holistic being as well as end-of-life, and the use of evidenced based practice in the clinical setting. The focus will be on nursing interventions for persons with alterations involving the respiratory, cardiovascular, neurological, genital/reproductive, and gastrointestinal systems, as well as those interventions required for persons experiencing multi-system failure. Interventions will be discussed in theory, applied in case scenarios, and in clinical settings. Prerequisites: NU 224, NU 230, NU 232, NU 240, and NU 260.